Semax 5MG Peptide - 99% Pure Peptide | PeptiUAE

Semax is a synthetic heptapeptide, an analogue of the adrenocorticotropic hormone (ACTH) fragment 4–10. It is a modification of the native ACTH(4–10) sequence, featuring the addition of a C-terminal Pro-Gly-Pro tripeptide which enhances its metabolic stability and bioavailability.

Scientific Overview

In laboratory and in vitro research, Semax is primarily studied for its potential neuroprotective and neurorestorative properties. Research has investigated its impact on several key biological pathways:

• Neurotrophic Factor Modulation: Studies have observed that Semax may upregulate the expression of brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, which are involved in neuronal survival and synaptic plasticity.

• Neurotransmitter Systems: Experimental data suggests it may modulate the brain's dopaminergic and serotonergic systems, which are relevant to cognitive and behavioral research.

• Oxidative Stress and Inflammation: In vitro models have been used to examine its antioxidant effects and its ability to modulate gene expression related to inflammatory responses in neural tissue.

Technical Specifications

• Chemical Name: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)

• Molecular Formula: C${37}$H${51}$N${9}$O${10}$S

• Molecular Weight: 813.92 g/mol

• Appearance: Typically supplied as a white to off-white lyophilized powder.

• Solubility: Soluble in water, PBS, and standard aqueous laboratory buffers.

• Analytical Verification: Identity and purity are typically confirmed via HPLC and mass spectrometry.

Storage and Handling

• Long-term Storage: Store at -20°C in a desiccated, moisture-free environment.

• Reconstitution: Usually reconstituted in sterile water or appropriate laboratory buffers.

• Stability: Avoid repeated freeze-thaw cycles once in solution to maintain structural integrity.

Research Use Disclaimer

For laboratory research purposes only. This material is not for human or veterinary use, nor for any cosmetic, food, or therapeutic applications. It is not approved by any regulatory agency for clinical use, and its safety profile in humans has not been established.