Kisspeptin 5MG Peptide - 99% Pure Peptide | PeptiUAE

Kisspeptin refers to a family of bioactive peptides encoded by the KISS1 gene. Originally identified in 1996 for its potential to suppress metastasis in melanoma cells (initially named "metastin"), it is now primarily recognized for its central role in regulating the mammalian reproductive axis.

Scientific Overview

In laboratory research, kisspeptin is studied for its function as an upstream mediator of the hypothalamic-pituitary-gonadal (HPG) axis:

• Mechanisms of Action: Kisspeptin binds to its specific receptor, the kisspeptin receptor (KISS1R, also known as GPR54). This interaction stimulates the secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus, which subsequently triggers the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland.

• Molecular Forms: The human KISS1 gene encodes a precursor protein that is proteolytically cleaved into several bioactive fragments, including kisspeptin-54 (KP-54), kisspeptin-14, kisspeptin-13, and kisspeptin-10. These variants act as agonists of KISS1R with similar affinity and efficacy.

• Research Applications: Current preclinical and clinical research explores the kisspeptin system as a therapeutic target for various reproductive hormonal disorders and metabolic conditions.

Technical Specifications

• Gene/Protein Source: Encoded by the KISS1 gene (humans).

• Receptor: KISS1R (G-protein coupled receptor).

• Biological Role: Regulator of GnRH secretion and the HPG axis.

• Storage: For laboratory-grade peptides, long-term storage is typically maintained at -20°C or lower in a desiccated, moisture-free environment. Avoid repeated freeze-thaw cycles once the material is reconstituted to maintain structural integrity.

Research Use Disclaimer

For laboratory research purposes only. This material is not for human or veterinary use, nor for any cosmetic, food, or therapeutic applications. It is not approved by any regulatory agency for clinical use.